Endocrine Abstracts

The main pathophysiological feature of type 2 diabetes mellitus is based on combination of impaired β-cell insulin secretion and insulin action in peripheral tissues. However, as progressive loss of the β-cells developes as a consequence of apoptosis, the insulin supply is later necessary. This picture is completely different in type 1 diabetes when insulin insufficiency is developed early in the disease and exogenous insulin is exagerated to maintain metabolic homeo...

Aim of the study: The aim of the study was to compare skin microvascular reactivity (MVR) with oxidative stress and metabolic parameters at fasting status and postprandially in patients with recently diagnosed type 2 diabetes.Methods: Twenty patients with type 2 diabetes (mean age 58±6 years, HbA1C 4.8±0.5%, diabetes duration 2.3±1.3 years, metformin treatment only) were included in the study. Blood samples were taken before and after 60, ...

Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in type 2 diabetes mellitus. The aim of this study was to develop a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in type 2 diabetic patients. Seventeen type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. In a mixe...

It is well known that hypercortisolism is associated with increased morbidity and mortality caused predominantly by vascular and atherosclerotic complications. The effect of hypercortisolism on microvasculature is less known. The aim of this study was to evaluate skin microvascular reactivity (MVR) in relation to arterial hypertension, diabetes mellitus and other possible influencing factors (fibrinolysis, oxidative stress and endothelial function) in patients with Cushing&#14...